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氫氯噻嗪

非售品
CAS:58-93-5
分子式:C7H8ClN3O4S2
分子量:297.74

結構式
    


CAS: 58-93-5
分子式: C7H8ClN3O4S2
分子量: 297.74

中文名稱: 氫氯噻嗪
      雙氫氯噻秦
      雙氫氯消痰
      雙氫克尿噻

英文名稱: hydrochlorothiazide

性狀描述: 白色結晶性粉末。溶點273-275℃,溶于丙酮,微溶于醇,不溶于水、氯仿、乙醚,溶于氫氧化鈉溶液,但易水解。味微苦。

生產方法: 由間氯苯胺經氯磺化得到5-氯-2,4-氯磺酰苯胺,再氨反應生成5-氯-2,4-氨磺苯胺,最后用甲醛歪合制得。

用途: 該品為噻嗪類中效利尿藥的典型代表,在美國1985年藥物銷售額排第一位。因服用方便,作用中等,且適用于各種水腫,因此是臨床上最常因有排鉀性不良反應,應用時需補充鉀鹽。小鼠靜永注射LD50為590mg/kg,口服LD50為大于8000mg/kg。  

亚洲综合小说另类图片五月天
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